Endocrine Abstracts

Aims: We aimed to investigate IGF1 and IGFBP3 gene polymorphisms in patients with acromegaly.Methods: We included 34 patients with acromegaly and 37 healthy subjects to study. At baseline examinations, antropometric measurements were done. Genomic DNA from the patients and controls were prepared. Serum, glucose, insulin, total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol, GH, IGF1 and IGFBP3 levels of subjects were analyzed.<p class="a...

Background: Acromegaly is associated with increased morbidity and mortality from cardiovascular disease. Hypertension is a number of common cardiovascular risk factors in acromegalic patients. The aim of this study was to investigate association between the frequencies of angiotensin converting enzyme (ACE) I/D and angiotensinogen (AGT) M235T polymorphisms, the genes belongs to the renin–angiotensin–aldosterone system, and clinical parameters of acromegaly patients.<...

Introduction: Kisspeptin is a 54-amino acid peptide, which comprise a diverse group of peptides with many different functions related to energy metabolism and reproduction, pubertal development. It activates GPR54 receptor. Subcutaneous administration of kisspeptin-54 to women with regular menstrual cycles results in an increase in LH and FSH. All these findings show that the GPR54 system may play a role in the function of the hypothalamic–pituitary–gonadal axis. PCO...

Introduction: Majority of polycystic ovary syndrome (PCOS) women are anovulatory, overweight/obese and insulin resistant. Kisspeptins are the endogenous ligands for GPR54 highly expressed in pancreas. Some studies showed that kisspeptins may play in the regulation of islet function and they stimulate insulin secretion from mouse and human islets. Adipose tissue acts as an endocrine organ and its function may be regulated by kisspeptins. We designed this study based on that obe...

Introduction: Generously supported by IPSEN)-->Acromegaly is a rare, chronic disorder, with classical clinical features caused by excess GH and consequent raised levels IGF1 and is associated with increased morbidity and mortality. Early diagnosis of the disease is very important for patient survival. Fetuin-A is a plasma glycoprotein that is produced by hepatocytes and it is the most important systemic calcification inhibitor. The p...

Introduction: Generously supported by IPSEN)-->Acromegaly is a rare, insidious, and potentially life-threatening condition. Patients with acromegaly have an increased morbidity and mortality for cardiovascular diseases. However, data on coronary heart disease and atherosclerosis are controversial in patients with acromegaly. Measurement of carotid intima media thickness (cIMT) with carotid doppler ultrasonography is a useful determin...

Introduction: Acromegaly is a rare disease that is most often caused by a GH secreting pituitary tumor. Apelin, a newly discovered peptide known as an endogenous ligand for its receptor (APJ) is a cardiac positive inotropic factor that has also hypotensive effects. The apelin and its receptor functions have not entirely been understood yet. The physiological importance of apelin, in acromegaly remains obscure.The aim of this study was to investigate the ...

Background: Hashimoto’s Thyroiditis (HT) is the most common clinical expression of thyroid dysfunction and result from organ-specific autoimmune reaction. Cytokines are play an important role in autoimmunity, by stimulating B and T cells.The aim of this study is to examine the relationship between cytokines and thyroid function tests in patient with Hashimoto’s ThyroiditisMethods: 139 cases with HT included this study. Su...

Background: Hashimoto’s thyroiditis is the most common autoimmune endocrine disorders and often leads to hypothyroidism. There is a relation with Vitamin D levels, vitamin D receptor (VDR) and HT reported. More than 30 gene polymorphisms are found in VDR gene. The most common four types of polymorphisms studied in autoimmune disease are FokI (exon 2), BsmI (intron 8), ApaI (intron 8) and TaqI (exon 9). The aim of this study is to investigate the association between VDR Fo...

Background: Hashimoto’s thyroiditis (HT) is one of the most common autoimmune thyroiditis that characterised by lymphocytic infiltration and thyroid hormonal disturbances. Genetic and environmental factors play a role in etiology of the disease, but genetic factors are most common. In this study, we investigated the association between Hashimoto’s thyroiditis and IL-2, IL-4, IL-5, TNF-α and IFN-γ levels.Methods: We performed a case&#1...